Deletion of retinoic acid receptor β (RARβ) impairs pancreatic endocrine differentiation

Volume: 319, Issue: 14, Pages: 2196 - 2204
Published: Aug 1, 2013
Abstract
All-trans retinoic acid (RA) signals via binding to retinoic acid receptors (RARs α, β, and γ). RA directly influences expression of Pdx1, a transcription factor essential for pancreatic development and beta-cell (β-cell) maturation. In this study we follow the differentiation of cultured wild-type (WT) vs. RARβ knockout (KO) embryonic stem (ES) cells into pancreatic islet cells. We found that RARβ KO ES cells show greatly reduced expression of...
Paper Details
Title
Deletion of retinoic acid receptor β (RARβ) impairs pancreatic endocrine differentiation
Published Date
Aug 1, 2013
Volume
319
Issue
14
Pages
2196 - 2204
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