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Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis: Outcomes from a Single Tertiary Institution

Published on May 1, 2014in Journal of Gastrointestinal Surgery2.686
· DOI :10.1007/s11605-014-2477-5
Parissa Tabrizian17
Estimated H-index: 17
(Mount Sinai Hospital),
Brian Shrager8
Estimated H-index: 8
(Morristown Medical Center)
+ 5 AuthorsDaniel M. Labow24
Estimated H-index: 24
(Mount Sinai Hospital)
Abstract
Background Cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC) is an effective but morbid procedure in the treatment of peritoneal carcinomatosis. We report our outcomes at a single tertiary institution.
  • References (30)
  • Citations (37)
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References30
Newest
#1L. H. Iversen (Aarhus University Hospital)H-Index: 5
#2P. C. Rasmussen (Aarhus University Hospital)H-Index: 5
Last. Søren Laurberg (Aarhus University Hospital)H-Index: 60
view all 3 authors...
Background: The outcome of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) depends on the extent of peritoneal carcinomatosis. The role of laparoscopy in the preoperative assessment of extent of peritoneal carcinomatosis in potential candidates for cytoreductive surgery and HIPEC was evaluated in a consecutive series. Methods: Patients with peritoneal carcinomatosis from colorectal cancer or appendiceal cancer, pseudomyxoma peritonei or peritoneal mesothelio...
61 CitationsSource
#1Dario BarattiH-Index: 42
#2Shigeki KusamuraH-Index: 36
Last. Marcello DeracoH-Index: 43
view all 6 authors...
OBJECTIVE: To assess the influence of parietal and visceral peritonectomy procedures on moderate/severe morbidity in patients undergoing surgical cytoreducion and hyperthermic intraperitoneal chemotherapy (HIPEC) and to identify subgroups of patients at highest operative risk. BACKGROUND: Cytoreducion with HIPEC is an effective but potentially morbid treatment option for peritoneal surface malignancies. Although complication rates have recently decreased with increasing experience, risk-factors ...
42 CitationsSource
#1Malin MörnerH-Index: 4
#2Ulf GunnarssonH-Index: 22
Last. Monika SvanfeldtH-Index: 1
view all 4 authors...
OBJECTIVE: This study tested the hypothesis that the amount of blood loss during surgery for colonic cancer influences long-term survival.BACKGROUND: The perioperative blood loss during surgery for ...
35 CitationsSource
#1Paul H. SugarbakerH-Index: 1
147 Citations
#1Franco Roviello (UNISI: University of Siena)H-Index: 34
#2Stefano Caruso (UNISI: University of Siena)H-Index: 12
Last. Enrico Pinto (UNISI: University of Siena)H-Index: 23
view all 7 authors...
Peritoneal carcinomatosis (PC) had long been regarded as a terminal disease, characterized by a very poor survival and worth treating with palliative therapy. A new strategy combining maximal surgery (cytoreductive surgery, CRS), with maximal regional chemotherapy (hyperthermic intraperitoneal chemotherapy, HIPEC), has been proposed to treat PC, resulting in long-term survival rates in selected patients. The emerging trend is to view localised peritoneal carcinomatosis, in the absence of other m...
71 CitationsSource
#1Terence C. Chua (St George's Hospital)H-Index: 35
#2Abdulaziz Al-Zahrani (St George's Hospital)H-Index: 1
Last. David L. Morris (St George's Hospital)H-Index: 65
view all 7 authors...
Background This study evaluates the accuracy of computed tomography (CT) scoring of the peritoneal cancer index (PCI) and examines its association with surgical morbidity and outcomes in pseudomyxoma peritonei.
32 CitationsSource
#1Jesus Esquivel (St. Agnes Hospital)H-Index: 20
#2Terence C. Chua (UNSW: University of New South Wales)H-Index: 35
Last. Robert P. Sticca (UND: University of North Dakota)H-Index: 13
view all 20 authors...
Background Evaluation of peritoneal metastases by computed tomography (CT) scans is challenging and has been reported to be inaccurate. Methods A multi-institutional prospective observational registry study of patients with peritoneal carcinomatosis from colorectal cancer was conducted and a subset analysis was performed to examine peritoneal cancer index (PCI) based on CT and intraoperative exploration. Results Fifty-two patients (mean age 52.6 ± 12.4 years) from 16 institutions were included i...
104 CitationsSource
#1Akshat Saxena (UNSW: University of New South Wales)H-Index: 30
#2Tristan D. Yan BSc Mbbs (UNSW: University of New South Wales)H-Index: 50
Last. David L. Morris (UNSW: University of New South Wales)H-Index: 65
view all 4 authors...
Background Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) has demonstrated improved survival in selected patients with pseudomyxoma peritonei (PMP). However, this aggressive treatment modality has been consistently associated with variable rates of perioperative mortality between 0% and 18% and morbidity between 30% and 70%. This study evaluates the clinical and treatment-related risk factors for perioperative morbidity and mortality in PMP patients wh...
50 CitationsSource
#1Terence C. Chua (UNSW: University of New South Wales)H-Index: 35
#2Akshat Saxena (UNSW: University of New South Wales)H-Index: 30
Last. David L. Morris (UNSW: University of New South Wales)H-Index: 65
view all 8 authors...
Introduction:Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) is a treatment option for peritoneal surface malignancy. Despite the survival benefits, this treatment was previously associated with a high morbidity and mortality rates and the perception of the
52 CitationsSource
#1Dominique Elias (Institut Gustave Roussy)H-Index: 82
Last. Olivier GlehenH-Index: 46
view all 9 authors...
Purpose Peritoneal carcinomatosis (PC) from colorectal cancer traditionally is considered a terminal condition. Approaches that combine cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) have been developed recently. The purpose of this study was to assess early and long-term survival in patients treated with that strategy. Patients and Methods A retrospective-cohort, multicentric study from French-speaking countries was performed. All consecutive patients with PC f...
549 CitationsSource
Cited By37
Newest
#1Natasha Leigh (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
#2D. Solomon (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
Last. B.J. Golas (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 3
view all 7 authors...
BACKGROUND Hepatopancreaticobiliary malignancies with peritoneal carcinomatosis exhibit poor survival with current therapies: hepatocellular carcinoma 11 months with sorafenib, and pancreaticobiliary 9-14 months with systemic chemotherapy. However, limited data exist on the utility of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in these patients. METHODS We retrospectively reviewed our institutional hepatopancreaticobiliary malignancies with peritoneal carcinomatosis whic...
Source
#1E.Y. Bekhor (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
#2Jacquelyn Carr (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
Last. Deepa Magge (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 9
view all 11 authors...
Offering iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for recurrence of peritoneal carcinomatosis (PC) poses a surgical dilemma. Safety of this repeated operation in the short and long term has not been largely investigated. Patients with PC who underwent 377 CRS/HIPEC procedures between 2007 and 2018 at our institution were included from a prospectively maintained database. Outcomes for patients who had singular CRS/HIPEC were compared with those for...
2 CitationsSource
Background The outcome of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) depends on the extent of peritoneal metastases (PM) and the completeness of cytoreduction (CCR). The role of preoperative assessment of PM is to identify potential candidates for CRS/HIPEC and to prevent unwarranted laparotomy for those who are not. Laparoscopy has been utilized for that purpose but with concerns related to technical difficulties and risk of trocar site metastases. Single-in...
Source
#2J. J. Segura-Sampedro (UIB: University of the Balearic Islands)
Last. Rafael Morales-SorianoH-Index: 1
view all 6 authors...
BACKGROUND AND OBJECTIVES: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is an effective but complex treatment for peritoneal metastasis (PM). Our objective was to identify risk factors for postoperative morbidity and mortality following CRS-HIPEC. METHODS: Retrospective study of prospectively collected data of patients undergoing CRS-HIPEC for PM arises from colorectal cancer between January 2008 and December 2017. Perioperative variables were correlated with ...
Source
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is increasingly used in peritoneal carcinomatosis (PC) management. This modality is criticized for its high morbidity and mortality. We evaluate the morbidity and mortality of patients undergoing this procedure in our institution. A review of our institution’s database was performed. All patients who underwent CRS/HIPEC between July 2011 and March 2018 were divided into three groups: no, low-grade, and high-grade c...
Source
#1Natasha Leigh (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
#2D. Solomon (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
Last. Daniel M. Labow (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 24
view all 7 authors...
Background Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is an aggressive locoregional treatment for peritoneal carcinomatosis (PC). Studies demonstrate improved perioperative and oncologic outcomes at high-volume centers.
1 CitationsSource
#1Brianne J. Sullivan (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 1
#1B. Sullivan (Mount Sinai St. Luke's and Mount Sinai Roosevelt)
Last. Benjamin J. Golas (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 1
view all 10 authors...
Background Pleural recurrence after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is rare and poorly delineated. Specifically, data are limited on the effect that diaphragmatic peritoneal stripping versus full-thickness resection has on the nature of ipsilateral pleural recurrence and postoperative morbidity.
1 CitationsSource
Purpose Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have become standard of care for many peritoneal malignancies in selected patients. Nevertheless, this aggressive treatment strategy is associated with significant major morbidity. The aim of the present study is to analyze the re-operation rate and clinical outcome following CRS and HIPEC.
Source
#1Daan D. Wisselink (UvA: University of Amsterdam)H-Index: 1
#2Linde L.F. Braakhuis (UvA: University of Amsterdam)H-Index: 1
Last. I.H.J.T. de HinghH-Index: 36
view all 9 authors...
Abstract Background The role of hyperthermic intraperitoneal chemotherapy (HIPEC) with oxaliplatin in addition to cytoreductive surgery (CRS) has recently been questioned in peritoneal metastases of colorectal cancer. Whether this applies to all published CRS/HIPEC regimens is unclear. Methods A systematic literature search identified 46 studies on CRS/HIPEC using either oxaliplatin of mitomycin C with at least one oncological outcome parameter Results Oxaliplatin and mitomycin C studies were co...
1 CitationsSource
#1Brianne J. Sullivan (Mount Sinai Hospital)
#2Nathan Bolton (Mount Sinai Hospital)
Last. Deepa Magge (Mount Sinai Hospital)
view all 4 authors...
Background Pseudomyxoma peritonei (PMP) is an uncommon condition characterized by diffuse mucinous material in the abdomen and pelvis, generally arising from a perforated epithelial neoplasm. Typically, the disease presents as suspected acute appendicitis, ovarian mass, abdominal distension, or ventral hernia. Our case represents a very rare presentation of superinfected PMP.
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