Combination of scaffold and adenovirus vectors expressing bone morphogenetic protein-7 for alveolar bone regeneration at dental implant defects

The current rapid progression in tissue engineering and local gene delivery systems has enhanced applications of osseointegration in dental implants. In this study, porous chitosan/collagen scaffolds were prepared through a freeze-drying process, and loaded with an adenoviral vector encoding human bone morphogenetic proteins (BMP7). These scaffolds were evaluated in vitro by scanning electron microscopy (SEM), and human periodontal ligament...