CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.

Volume: 112, Issue: 6, Pages: 1815 - 1820
Published: Feb 10, 2015
Abstract
Ig heavy chain (IgH) variable region exons are assembled from V, D, and J gene segments during early B-lymphocyte differentiation. A several megabase region at the “distal” end of the mouse IgH locus (Igh) contains hundreds of VHs, separated by an intergenic region from Igh Ds, JHs, and constant region exons. Diverse primary Igh repertoires are generated by joining Vs, Ds, and Js in different combinations, with a given B cell productively...
Paper Details
Title
CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.
Published Date
Feb 10, 2015
Volume
112
Issue
6
Pages
1815 - 1820
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