(−)-α-Bisabolol attenuates visceral nociception and inflammation in mice

The study examined the antiinflammatory and antinociceptive effects of the sesquiterpene (−)-α-bisabolol (BISA). The antiinflammatory effect was evaluated on acute models of dermatitis induced by Croton oil, arachidonic acid, phenol and capsaicin, respectively, in mouse ear. BISA inhibited the dermatitis induced by all noxious agents, except capsaicin. BISA was assessed in two established mouse models of visceral nociception. Mice were...