Diagnosing Abnormal Glucose Tolerance in Hypertensive Women: Are We Making the Best Choice?

Published on Feb 1, 2007in Journal of The Cardiometabolic Syndrome
· DOI :10.1111/j.1559-4564.2007.06482.x
Lydia Sebba Souza Mariosa2
Estimated H-index: 2
(UNIFESP: Federal University of São Paulo),
Fernando Flexa Ribeiro-Filho10
Estimated H-index: 10
(UNIFESP: Federal University of São Paulo)
+ 1 AuthorsMaria Teresa Zanella19
Estimated H-index: 19
(UNIFESP: Federal University of São Paulo)
Essential hypertension is a condition of peripheral insulin resistance; thus, fasting plasma glucose level (FPG) alone may not identify glucose tolerance abnormalities. To evaluate the value of an FPG of 100 mg/dL in the detection of these abnormalities in hypertensive women and to identify clinical markers of a high risk of glucose intolerance indicative of further investigation, the authors studied 313 hypertensive women, without known diabetes, in whom an oral glucose tolerance test (OGTT) was performed. The authors demonstrated that FPG alone was not sufficient to identify 27.6% of hypertensive women with glucose intolerance. In this subgroup, the association of waist circumference ≥97 cm and FPG ≥100 mg/dL increased the risk of glucose intolerance with an odds ratio of 6.97. The authors suggest that OGTT should be performed in hypertensive women with normal FPG but with FPG ≥90 mg/dL or waist circumference ≥97 cm.
  • References (49)
  • Citations (1)
📖 Papers frequently viewed together
22 Citations
47 Citations
3 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
32 Citations
#1Hertzel C. Gerstein (Population Health Research Institute)H-Index: 93
#2Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
Last. Jackie Bosch (Population Health Research Institute)H-Index: 45
view all 3 authors...
236 CitationsSource
Background: Rosiglitazone is a thiazolidinedione that reduces insulin resistance and might preserve insulin secretion. The aim of this study was to assess prospectively the drug's ability to prevent type 2 diabetes in individuals at high risk of developing the condition. Methods: 5269 adults aged 30 years or more with impaired fasting glucose or impaired glucose tolerance, or both, and no previous cardiovascular disease were recruited from 191 sites in 21 countries and randomly assigned to recei...
1,386 CitationsSource
#1Christian MeyerH-Index: 32
Last. John E. GerichH-Index: 79
view all 7 authors...
OBJECTIVE —To compare the pathophysiology of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) in a more comprehensive and standardized fashion than has hitherto been done. RESEARCH DESIGN AND METHODS —We studied 21 individuals with isolated IFG (IFG/normal glucose tolerance [NGT]), 61 individuals with isolated IGT (normal fasting glucose [NFG]/IGT), and 240 healthy control subjects (NFG/NGT) by hyperglycemic clamps to determine first- and second-phase insulin release and insul...
196 CitationsSource
#1Eric N. TaylorH-Index: 31
#2Frank B. HuH-Index: 205
Last. Gary C. CurhanH-Index: 111
view all 3 authors...
OBJECTIVE —The purpose of this study was to examine the association between the use of different classes of antihypertensive medications and the risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS —We conducted a prospective study of three cohorts: the Nurses’ Health Study (NHS) I and II and the Health Professionals Follow-up Study (HPFS). Antihypertensive medication use was ascertained by biennial questionnaires. After excluding participants who reported a history of diabetes at basel...
109 CitationsSource
#1Eric J. BrunnerH-Index: 89
#2Martin J. ShipleyH-Index: 101
Last. Michael MarmotH-Index: 169
view all 5 authors...
Objective: Glucose intolerance is a risk factor for coronary disease, but there is uncertainty about the shape of the dose-response relationship between glucose level and risk of coronary mortality. We examined the prospective relation of 2-h postload blood glucose (2hBG) with coronary and other major causes of mortality over 33 years. Research Design and Methods:A 50-g oral glucose tolerance test (OGTT) was performed at baseline (1967–1969) in 17,869 male civil servants aged 40–64 years. Result...
116 CitationsSource
#1Amir Tirosh (BGU: Ben-Gurion University of the Negev)H-Index: 26
#2Iris ShaiH-Index: 39
Last. Assaf RudichH-Index: 50
view all 8 authors...
Background The normal fasting plasma glucose level was recently defined as less than 100 mg per deciliter (5.55 mmol per liter). Whether higher fasting plasma glucose levels within this range independently predict type 2 diabetes in young adults is unclear. Methods We obtained blood measurements, data from physical examinations, and medical and lifestyle information from men in the Israel Defense Forces who were 26 to 45 years of age. Results A total of 208 incident cases of type 2 diabetes occu...
386 CitationsSource
#1Yu KataokaH-Index: 24
#2Satoshi YasudaH-Index: 35
Last. Shunichi MiyazakiH-Index: 37
view all 6 authors...
OBJECTIVE —We investigated the morphological characteristics of coronary arteries in patients with impaired glucose tolerance (IGT) using computer-assisted quantitative coronary angiography. IGT is an independent risk factor for cardiovascular disease. However, the morphological changes developing in the coronary arteries of patients with IGT remain unknown. RESEARCH DESIGN AND METHODS —A total of 534 patients with angina pectoris were studied. Of these, 144 patients were being treated for diabe...
35 CitationsSource
#1S. Lüders (Aventis Pharma)H-Index: 1
#2F. Hammersen (Aventis Pharma)H-Index: 1
Last. J. Schrader (Aventis Pharma)H-Index: 1
view all 11 authors...
Summary Many patients with hypertension suffer from impaired glucose tolerance or type 2 diabetes mellitus. Although these diagnoses are generally simple and reliable, it is more difficult to diagnose impaired glucose tolerance. As the gold standard (oral glucose tolerance test (OGTT)) is complicated to perform, a simpler alternative would be useful. The aims of the Pre-Diabetes Score study are to correlate demographic and/or laboratory parameters that are clinically simple to determine with the...
13 CitationsSource
#1Raj S. PadwalH-Index: 45
#2Sumit R. MajumdarH-Index: 70
Last. Finlay A. McAlisterH-Index: 83
view all 5 authors...
OBJECTIVE —To systematically review the evidence for the prevention of type 2 diabetes by pharmacological therapies. RESEARCH DESIGN AND METHODS —Randomized controlled trials and cohort studies examining the effect of oral hypoglycemic agents, antiobesity agents, antihypertensive agents, statins, fibrates, and estrogen on the incidence of type 2 diabetes were identified from MEDLINE, EMBASE, the Cochrane Controlled Trials Registry, and searches of reference lists. Two reviewers independently ass...
149 CitationsSource
Cited By1
#1Chen YxH-Index: 1
#2Wang XqH-Index: 1
Last. Wei YlH-Index: 1
view all 8 authors...
Glucometabolic state of in-hospital patients with primary hypertension in sub-population of partial regions in China
4 CitationsSource