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Diagnosing Abnormal Glucose Tolerance in Hypertensive Women: Are We Making the Best Choice?

Published on Feb 1, 2007in Journal of The Cardiometabolic Syndrome
· DOI :10.1111/j.1559-4564.2007.06482.x
Lydia Sebba Souza Mariosa2
Estimated H-index: 2
(UNIFESP: Federal University of São Paulo),
Fernando Flexa Ribeiro-Filho10
Estimated H-index: 10
(UNIFESP: Federal University of São Paulo)
+ 1 AuthorsMaria Teresa Zanella19
Estimated H-index: 19
(UNIFESP: Federal University of São Paulo)
Abstract
Essential hypertension is a condition of peripheral insulin resistance; thus, fasting plasma glucose level (FPG) alone may not identify glucose tolerance abnormalities. To evaluate the value of an FPG of 100 mg/dL in the detection of these abnormalities in hypertensive women and to identify clinical markers of a high risk of glucose intolerance indicative of further investigation, the authors studied 313 hypertensive women, without known diabetes, in whom an oral glucose tolerance test (OGTT) was performed. The authors demonstrated that FPG alone was not sufficient to identify 27.6% of hypertensive women with glucose intolerance. In this subgroup, the association of waist circumference ≥97 cm and FPG ≥100 mg/dL increased the risk of glucose intolerance with an odds ratio of 6.97. The authors suggest that OGTT should be performed in hypertensive women with normal FPG but with FPG ≥90 mg/dL or waist circumference ≥97 cm.
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  • Citations (1)
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References49
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Background: Rosiglitazone is a thiazolidinedione that reduces insulin resistance and might preserve insulin secretion. The aim of this study was to assess prospectively the drug's ability to prevent type 2 diabetes in individuals at high risk of developing the condition. Methods: 5269 adults aged 30 years or more with impaired fasting glucose or impaired glucose tolerance, or both, and no previous cardiovascular disease were recruited from 191 sites in 21 countries and randomly assigned to recei...
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#1Eric J. BrunnerH-Index: 89
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#1Yu KataokaH-Index: 24
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Summary Many patients with hypertension suffer from impaired glucose tolerance or type 2 diabetes mellitus. Although these diagnoses are generally simple and reliable, it is more difficult to diagnose impaired glucose tolerance. As the gold standard (oral glucose tolerance test (OGTT)) is complicated to perform, a simpler alternative would be useful. The aims of the Pre-Diabetes Score study are to correlate demographic and/or laboratory parameters that are clinically simple to determine with the...
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