Resveratrol inhibits lipopolysaccharide-induced phagocytotic activity in BV2 cells

The inhibitory effects of resveratrol, a natural bioactive polyphenolic phytoalexin rich in grape, on lipopolysaccharide (LPS)-induced microglial activation and its beneficial effects on dopaminergic neurodegeneration were studied. Resveratrol dosedependently suppressed LPS-induced nitric oxide production and the expression of inducible NO synthase (iNOS) in BV-2 microglial cells. Furthermore, resveratrol (1 μM) significantly blocked BV2...