Involvement of GABAA-benzodiazepine receptor in the anxiolytic effect induced by hexanic fraction of Rubus brasiliensis
Abstract
To investigate the ability of hexanic ethanolic fraction of Rubus brasiliensis Martius (Roseceae), to induce anxiolytic effect and also the possible involvement of the GABA(A)-benzodiazepine receptor complex, male Wistar rats and Swiss mice behaviour were tested in the elevated plus maze (EPM). All the doses of the extract, 50, 100 and 150 mg/kg, administered per gavage (vo), 30 min before the behavioural evaluation, induced an anxiolytic effect...
Paper Details
Title
Involvement of GABAA-benzodiazepine receptor in the anxiolytic effect induced by hexanic fraction of Rubus brasiliensis
Published Date
Jun 1, 1998
Journal
Volume
61
Issue
2
Pages
119 - 126
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