It takes two to tango: combined amylin/leptin agonism as a potential approach to obesity drug development.
Abstract
The discovery of leptin in 1994 was a seminal event in obesity research. It helped to establish that body weight is tightly regulated by a complex neurohormonal feedback system and that obesity should be viewed as a disorder with a strong biological basis rather than simply the result of poor lifestyle choices and lack of willpower.Leptin, secreted from adipocytes, acts as a prototypic long-term (tonic) adiposity signal. Although nonclinical and...
Paper Details
Title
It takes two to tango: combined amylin/leptin agonism as a potential approach to obesity drug development.
Published Date
Oct 1, 2009
Volume
57
Issue
7
Pages
777 - 783
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