Match!

Neuropsychological Features of Asymptomatic c.709-1G>A Progranulin Mutation Carriers *

Published on Nov 1, 2012in Journal of The International Neuropsychological Society3.10
· DOI :10.1017/S1355617712000823
Myriam Barandiaran8
Estimated H-index: 8
,
Ainara Estanga11
Estimated H-index: 11
+ 5 AuthorsAdolfo López de Munain33
Estimated H-index: 33
Abstract
Mutations in the progranulin (PGRN) gene have been identified as a cause of frontotemporal dementia (FTD). However, little is known about the neuropsychological abilities of asymptomatic carriers of these mutations. The aim of the study was to assess cognitive functioning in asymptomatic c.709-1G>A PGRN mutation carriers. We hypothesized that poorer neuropsychological performance could be present before the development of clinically significant FTD symptoms. Thirty-two asymptomatic first-degree relatives of FTD patients carrying the c.709-1G>A mutation served as study participants, including 13 PGRN mutation carriers (A-PGRN+) and 19 non-carriers (PGRN-). A neuropsychological battery was administered. We found that the A-PGRN+ participants obtained significantly poorer scores than PGRN- individuals on tests of attention (Trail-Making Test Part A), mental flexibility (Trail-Making Test Part B), and language (Boston Naming Test). Poorer performance on these tests in asymptomatic PGRN mutation carriers may reflect a prodromal phase preceding the onset of clinically significant symptoms of FTD. ( JINS , 2012, 18 , 1086–1090)
  • References (20)
  • Citations (11)
References20
Newest
#1Jacqueline MulderH-Index: 5
#2S. ScholteH-Index: 1
Last.J.M. BoumaH-Index: 5
view all 3 authors...
74 Citations
121 CitationsSource
#1Fred TamH-Index: 13
#2Nathan W. Churchill (U of T: University of Toronto)H-Index: 17
Last.Simon J. Graham (U of T: University of Toronto)H-Index: 43
view all 4 authors...
47 CitationsSource
#1PhilosophieH-Index: 1
30 Citations
#1Jonathan D. Rohrer (UCL Institute of Neurology)H-Index: 50
#2Sebastian J. Crutch (UCL Institute of Neurology)H-Index: 35
Last.Jason D. Warren (UCL Institute of Neurology)H-Index: 59
view all 4 authors...
59 CitationsSource
#1Andrew Bateman (MUHC: McGill University Health Centre)H-Index: 30
#2Hugh P. J. Bennett (MUHC: McGill University Health Centre)H-Index: 33
215 CitationsSource
#1Fermín MorenoH-Index: 4
Last.A. López de MunainH-Index: 24
view all 11 authors...
23 CitationsSource
104 CitationsSource
#1Teresa Torralva (Favaloro University)H-Index: 31
#2María Roca (Favaloro University)H-Index: 19
Last.Facundo Manes (Favaloro University)H-Index: 54
view all 5 authors...
180 CitationsSource
#1Roberta GhidoniH-Index: 40
#2Luisa BenussiH-Index: 38
Last.G. BinettiH-Index: 23
view all 5 authors...
217 CitationsSource
Cited By11
Newest
Source
#1Adam M. Staffaroni (UCSF: University of California, San Francisco)H-Index: 5
#2Lynn Bajorek (UCSF: University of California, San Francisco)H-Index: 1
Last.Howie Rosen (UCSF: University of California, San Francisco)H-Index: 62
view all 92 authors...
Source
Source
#1Lize C. Jiskoot (EUR: Erasmus University Rotterdam)H-Index: 9
#2Jessica L. Panman (EUR: Erasmus University Rotterdam)H-Index: 5
Last.Janne M. Papma (EUR: Erasmus University Rotterdam)H-Index: 9
view all 13 authors...
7 CitationsSource
#1Carolina Alquézar (CSIC: Spanish National Research Council)H-Index: 8
#2Irene G. Salado (CSIC: Spanish National Research Council)H-Index: 5
Last.Ángeles Martín-Requero (CSIC: Spanish National Research Council)H-Index: 15
view all 9 authors...
9 CitationsSource
#1Lize C. JiskootH-Index: 4
#2Elise G.P. DopperH-Index: 16
Last.Janne M. PapmaH-Index: 9
view all 7 authors...
15 CitationsSource
#1Carolina Alquézar (CSIC: Spanish National Research Council)H-Index: 5
#2Noemí Esteras (CSIC: Spanish National Research Council)H-Index: 12
Last.Ángeles Martín-Requero (CSIC: Spanish National Research Council)H-Index: 15
view all 6 authors...
9 CitationsSource
#1Vincenzo Paolo Senese (Seconda Università degli Studi di Napoli)H-Index: 12
#2Natascia De Lucia (Seconda Università degli Studi di Napoli)H-Index: 7
Last.Massimiliano Conson (Seconda Università degli Studi di Napoli)H-Index: 20
view all 3 authors...
7 CitationsSource
3 CitationsSource
#1Bradley J. Hallam (UBC: University of British Columbia)H-Index: 5
#2Claudia Jacova (UBC: University of British Columbia)H-Index: 22
Last.Ian R. A. Mackenzie (UBC: University of British Columbia)H-Index: 80
view all 13 authors...
8 CitationsSource
View next paperMutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.