A Search for High Molecular Impurities in Penicillin G

A search for high molecular residues in penicillin G was carried out using several recently described methods. By the membrane filtration method the protein content of a large number of batches of penicillin G, 6-APA (chemically prepared), and ampicillin was determined. Significantly lower protein values were found for these compounds than for microbiologically produced 6-APA and the ampicillin made from it. Purified macromolecular complexes of...