Calcium Phosphate Microspheres for Localised Delivery of a Therapeutic Enzyme

Volume: 309-311, Pages: 903 - 906
Published: May 1, 2006
Abstract
The ability of calcium titanium phosphate (CTP) and hydroxyapatite (HAp) microspheres to reversibly adsorb the enzyme glucocerebrosidase (GCR) while preserving its biological activity, and efficiently deliver it to Gaucher disease (GD) fibroblasts was investigated. CTP microspheres adsorbed ca. 3.6-fold more GCR than HAp microspheres. The activity of adsorbed GCR was higher than the free enzyme in the case of CTP microspheres and lower when HAp...
Paper Details
Title
Calcium Phosphate Microspheres for Localised Delivery of a Therapeutic Enzyme
Published Date
May 1, 2006
Volume
309-311
Pages
903 - 906
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