p53: The barrier to cancer stem cell formation
Abstract
The role of p53 as the “guardian of the genome” in differentiated somatic cells, triggering various biological processes, is well established. Recent studies in the stem cell field have highlighted a profound role of p53 in stem cell biology as well. These studies, combined with basic data obtained 20 years ago, provide insight into how p53 governs the quantity and quality of various stem cells, ensuring a sufficient repertoire of normal stem...
Paper Details
Title
p53: The barrier to cancer stem cell formation
Published Date
Feb 19, 2014
Journal
Volume
588
Issue
16
Pages
2580 - 2589
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Notes
History