Cell-Specific Transcriptional Regulation of Follicle-Stimulating Hormone-β by Activin and Gonadotropin-Releasing Hormone in the LβT2 Pituitary Gonadotrope Cell Model1
Abstract
FSH is secreted by gonadotropes of the anterior pituitary and plays a crucial role in mammalian reproduction. However, little is known about FSH gene regulation due to the lack of a gonadotrope cell line that synthesizes FSH. The LβT2 mouse pituitary cell line, isolated by targeted tumorigenesis in transgenic mice, has the characteristics of a mature gonadotrope, including expression of GnRH receptor, steroidogenic factor 1, and both the α- and...
Paper Details
Title
Cell-Specific Transcriptional Regulation of Follicle-Stimulating Hormone-β by Activin and Gonadotropin-Releasing Hormone in the LβT2 Pituitary Gonadotrope Cell Model1
Published Date
Jun 1, 2001
Journal
Volume
142
Issue
6
Pages
2284 - 2295
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