The translation of translational control by FMRP: therapeutic targets for FXS
Abstract
De novo protein synthesis is necessary for long-lasting modifications in synaptic strength and dendritic spine dynamics that underlie cognition. Fragile X syndrome (FXS), characterized by intellectual disability and autistic behaviors, holds promise for revealing the molecular basis for these long-term changes in neuronal function. Loss of function of the fragile X mental retardation protein (FMRP) results in defects in synaptic plasticity and...
Paper Details
Title
The translation of translational control by FMRP: therapeutic targets for FXS
Published Date
Nov 1, 2013
Journal
Volume
16
Issue
11
Pages
1530 - 1536
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