Tryptophan metabolism in cirrhotic patients with and without manifestations of overt hepatic encepahlopathy

Introduction

Patients with hepatic encephalopathy have an altered sleep pattern. Tryptophan metabolism produces two sedative compounds oxindole and melatonin. Altered tryptophan metabolism in patients with hepatic encephalopathy could have some role in the pathogenesis of the disease.

Aim

The study aim was to study differences in the concentrations of oxindole and melatonin between various parts of the body in cirrhotics with...