Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress.

Volume: 20, Issue: 12, Pages: 1417 - 1426
Published: Dec 1, 2014
Abstract
In type 2 diabetes, hyperglycemia is present when an increased demand for insulin, typically due to insulin resistance, is not met as a result of progressive pancreatic beta cell dysfunction. This defect in beta cell activity is typically characterized by impaired insulin biosynthesis and secretion, usually accompanied by oxidative and endoplasmic reticulum (ER) stress. We demonstrate that multiple inflammatory cytokines elevated in diabetic...
Paper Details
Title
Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress.
Published Date
Dec 1, 2014
Volume
20
Issue
12
Pages
1417 - 1426
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