NOD1 and NOD2: signaling, host defense, and inflammatory disease.

Volume: 41, Issue: 6, Pages: 898 - 908
Published: Dec 18, 2014
Abstract
The nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2, the founding members of the intracellular NOD-like receptor family, sense conserved motifs in bacterial peptidoglycan and induce proinflammatory and antimicrobial responses. Here, we discuss recent developments about the mechanisms by which NOD1 and NOD2 are activated by bacterial ligands, the regulation of their signaling pathways, and their role in host defense and...
Paper Details
Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
Published Date
Dec 18, 2014
Journal
Volume
41
Issue
6
Pages
898 - 908
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