Lighter: fast and memory-efficient sequencing error correction without counting
Abstract
Lighter is a fast, memory-efficient tool for correcting sequencing errors. Lighter avoids counting k-mers. Instead, it uses a pair of Bloom filters, one holding a sample of the input k-mers and the other holding k-mers likely to be correct. As long as the sampling fraction is adjusted in inverse proportion to the depth of sequencing, Bloom filter size can be held constant while maintaining near-constant accuracy. Lighter is parallelized, uses no...
Paper Details
Title
Lighter: fast and memory-efficient sequencing error correction without counting
Published Date
Nov 1, 2014
Journal
Volume
15
Issue
11
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