Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report
Abstract
Amyloid-beta peptide (Abeta) has a key role in the pathogenesis of Alzheimer disease (AD). Immunization with Abeta in a transgenic mouse model of AD reduces both age-related accumulation of Abeta in the brain and associated cognitive impairment. Here we present the first analysis of human neuropathology after immunization with Abeta (AN-1792). Comparison with unimmunized cases of AD (n = 7) revealed the following unusual features in the...
Paper Details
Title
Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report
Published Date
Mar 17, 2003
Journal
Volume
9
Issue
4
Pages
448 - 452
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