The ATM tumour suppressor gene is down‐regulated in EBV‐associated nasopharyngeal carcinoma
Abstract
A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or absent in almost all cases. In NPC...
Paper Details
Title
The ATM tumour suppressor gene is down‐regulated in EBV‐associated nasopharyngeal carcinoma
Published Date
Jan 13, 2009
Journal
Volume
217
Issue
3
Pages
345 - 352
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