Synergetic Effect of a-Lipoic Acid with Keratinocyte Growth Factor on Protecting Alveolar Epithelial Type II Cells of Rat Fetus from Hyperoxia -Induced Injury

Aim: To explore the potential mechanism of the synergetic effect of α-lipoic acid with keratinocyte growth factor (KGF) on protecting alveolar epithelial type II cells (ATIICs) from hyperoxia-induced injury. Methods: Primary culture of ATIICs from the Sprague-Dawley rat fetuses was examined under room air and 95% of O2. Various KGF concentrations (0 to 100 ng/mL) and 0.5 mM of α-lipoic were added into the cell culture. Levels of intracellular...