Match!

Biomimetic Membrane System Composed of a Composite Interpenetrating Hydrogel Film and a Lipid Bilayer

Published on Oct 23, 2012in Advanced Functional Materials15.621
路 DOI :10.1002/adfm.201200751
Barry Stidder2
Estimated H-index: 2
(UJF: Joseph Fourier University),
Jean-Pierre Alcaraz6
Estimated H-index: 6
(UJF: Joseph Fourier University)
+ 5 AuthorsDonald Martin1
Estimated H-index: 1
(UJF: Joseph Fourier University)
Abstract
A simple way to form an interpenetrating hydrogel (IPH) by combining a layer-by-layer polyelectrolyte membrane with agarose is reported. The formed IPH membrane is more robust and easily manipulated compared to a polyelectrolyte membrane with the same number of layers. The IPH has good diffusion characteristics and retains the advantageous surface charge from the polyectrolyte composition that facilitates the adsorption of a stable lipid bilayer. The stable adsorption of a lipid bilayer on the IPH creates a biomimetic membrane system that is optimized for utilization in a diffusion chamber.
  • References (35)
  • Citations (5)
馃摉 Papers frequently viewed together
2 Citations
19962.67FEBS Letters
3 Authors (Tianru Jin, ..., P.I. Lee)
46 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References35
Newest
#1Damien Mertz (University of Melbourne)H-Index: 14
#2Pramudana Tan (University of Melbourne)H-Index: 2
Last. Fabrizio Caruso (University of Melbourne)H-Index: 101
view all 6 authors...
30 CitationsSource
The diffusion coefficient is a fundamental parameter for devices exploiting the ion transport properties of polyelectrolyte multilayers (PEMUs) and complexes. Here, the transport of ferricyanide through a multilayer made from poly(diallyldimethylammonium chloride) (PDADMA) and polystyrene sulfonate (PSS) was studied as a function of temperature or salt concentration. Accurate and precise measurements of ion diffusion coefficients were obtained using steady-state electrochemistry to determine the...
28 CitationsSource
#1Liju Yang (NCCU: North Carolina Central University)H-Index: 4
Last. Anthony Guiseppi-Elie (Clemson University)H-Index: 34
view all 3 authors...
Microlithographically fabricated interdigitated microsensor electrodes (IMEs) were cleaned, surface activated, chemically functionalized (amine) and derivatized with an Acrloyl-PEG-NHS to receive a spun-applied monomer cocktail of UV polymerizable monomer. IMEs were 2050.5, 1550.5, 1050.5 and 0550.5 possessing lines and spaces that were 20, 15, 10, and 5 渭m respectively; 5 mm line lengths and were 50 lines on each opposing bus. Bioactive hydrogels were synthesized from spun-applied and UV-crossl...
27 CitationsSource
#1Leticia Hosta-Rigau (University of Melbourne)H-Index: 22
#2Rona Chandrawati (University of Melbourne)H-Index: 17
Last. Fabrizio Caruso (University of Melbourne)H-Index: 101
view all 10 authors...
We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMAc) to noncovalently anchor liposomes to polymer layers. We subsequently assembled 鈭1 渭m diameter PMAc-based capsosomes, polymer hydrogel capsules that contain up to 鈭2000 liposomal subcompartments, and investigate the potential of these carriers to deliver water-...
44 CitationsSource
#1Emiliano Fern谩ndez (CSIC: Spanish National Research Council)H-Index: 4
#2Rebeca Hern谩ndez (CSIC: Spanish National Research Council)H-Index: 19
Last. Daniel L贸pez (CSIC: Spanish National Research Council)H-Index: 29
view all 5 authors...
In this article, we report on the viscoelastic and thermal properties of agarose-polyacrylamide (PAAm) inter- penetrating polymer hydrogels (IPHs) and semi-IPHs as a function of agarose concentration and PAAm crosslinking degree. The results demonstrated that the agarose is able to gel in the presence of crosslinked and linear IPHs. In addition, the reticulation of PAAm in the presence of agarose is con- firmed for the case of IPHs giving rise to systems with dimen- sional stability at high temp...
8 CitationsSource
Neutron reflection has become a popular tool to study supported lipid membranes, demonstrating the advantages of the structural and compositional insights given by H/D contrast variation in biophysical membrane studies. While technical advances such as magnetic contrast variation and new data-analysis techniques have increased the accuracy of data modeling and interpretation, the use of complementary techniques has widened the range of membrane applications studied and allowed the investigation ...
61 CitationsSource
#1Abdoul-Nasser Dirieh Egueh (UFC: University of Franche-Comt茅)H-Index: 1
#2Boris Lakard (UFC: University of Franche-Comt茅)H-Index: 22
Last. C.C. Buron (UFC: University of Franche-Comt茅)H-Index: 13
view all 5 authors...
Alternate adsorption of polyanions and polycations on a polyethersulfone (PES) membrane was studied by the tangential streaming potential method using a parallel-plate channel to investigate the properties of the outer surface of the membrane. These streaming potential data were complemented by diffusion experiments and by membrane potential measurements in order to characterize the inner surface of the membrane. Tangential streaming potential measurements demonstrated that after completing a bi...
25 CitationsSource
#1Tom谩s J. Madera-Santana (CINVESTAV)H-Index: 8
#2Manjusri Misra (U of G: University of Guelph)H-Index: 63
Last. Yolanda Freile-Pelegr铆n (CINVESTAV)H-Index: 21
view all 5 authors...
A series of biocomposites were developed by reinforcing agar particles from red marine plant Gelidium robustum into poly(butylene adipate-co-terephatalate) (PBAT) using extrusion and injection molding technique. The effect of different content of agar (0, 10, 20, 30, and 40 wt%) on the physico-mechanical properties of the biocomposite was evaluated. The dynamic mechanical behavior of the composites was studied to determine the storage and loss modulus. The incorporation of agar particles into PB...
35 CitationsSource
#1Andrew R. Battle (UTS: University of Technology, Sydney)H-Index: 15
#2Stella M. Valenzuela (UTS: University of Technology, Sydney)H-Index: 28
Last. Donald K. Martin (UTS: University of Technology, Sydney)H-Index: 20
view all 13 authors...
The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules Is reported. A novel engineered ion channel, gramicidin (bis-gA), incorporated Into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, a...
24 CitationsSource
#1Jiangshan Chen (MPG: Max Planck Society)H-Index: 2
#2Ralf K枚hler (MPG: Max Planck Society)H-Index: 9
Last. Rumen Krastev (MPG: Max Planck Society)H-Index: 22
view all 5 authors...
Lipid bilayer of 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) was formed on the surface of a linearly growing polyanion/polycation polyelectrolyte multilayer (PEM) film prepared by the layer-by-layer (LbL) technique. The PEM films were prepared with two strong polyelectrolytes鈥攑oly(sodium 4-styrenesulfonate) (PSS) as the polyanion and poly-(diallyldimethylammonium chloride) (PDADMAC) as the polycation. The DMPE was always deposited onto the PEM cushion terminated with positively charg...
16 CitationsSource
Cited By5
Newest
#1Awatef Ben Tahar (French Institute of Health and Medical Research)
#2Abdelkader Zebda (French Institute of Health and Medical Research)H-Index: 12
Last. Donald K. Martin (French Institute of Health and Medical Research)H-Index: 20
view all 7 authors...
We designed a supported lipid bilayer (SLB) biomimetic membrane system that comprised polyaniline (PANI) to support a lipid bilayer membrane that incorporated Na+/H+ transporter proteins (NhaA) to give the system the capability of controllable electrogenic ion transport. The high turnover rate of NhaA (鈭105 per min) provides the basis for this PANI-SLB-NhaA system to be a high-speed rechargeable biocapacitor that functions as a low-energy-consuming fast switch for biological engineering applicat...
Source
#1Abir Khalil鈥怣gharbel (CNRS: Centre national de la recherche scientifique)H-Index: 1
#2Helena Polena (CNRS: Centre national de la recherche scientifique)H-Index: 1
Last. Isabelle Vilgrain (CNRS: Centre national de la recherche scientifique)H-Index: 1
view all 7 authors...
1 CitationsSource
#1Nathalie Picollet-D鈥檋ahan (French Institute of Health and Medical Research)H-Index: 11
#2Monika E. Dolega (French Institute of Health and Medical Research)H-Index: 6
Last. Donald K. Martin (CNRS: Centre national de la recherche scientifique)H-Index: 20
view all 7 authors...
We discuss the current challenges and future prospects of flow-based organoid models and 3D self-assembling scaffolds. The existing paradigm of 3D culture suffers from a lack of control over organoid size and shape; can be an obstacle for cell harvesting and extended cellular and molecular analysis; and does not provide access to the function of exocrine glands. Moreover, existing organ-on-chip models are mostly composed of 2D extracellular matrix (ECM)-coated elastomeric membranes that do not m...
26 CitationsSource
#1Lavinia Liguori (UGA: University of Grenoble)H-Index: 1
#2Barry Stidder (UGA: University of Grenoble)H-Index: 1
Last. Donald K. Martin (UGA: University of Grenoble)H-Index: 2
view all 6 authors...
The mitochondrial voltage-dependent anion channel (VDAC) is a pivotal protein since it provides the major transport pathway between the cytosol and the mitochondrial intermembrane space and it is implicated in cell apoptosis by functioning as a gatekeeper for the trafficking of mitochondrial death molecules. VDAC is a beta-barrel channel with a large conductance, and we use it as a model transport protein for the design of biomimetic systems. To overcome the limitations of classical overexpressi...
2 CitationsSource
#1Bom-yi LeeH-Index: 3
#2Seung Hyup HyunH-Index: 9
Last. Jin Kon KimH-Index: 42
view all 7 authors...
Stimuli-responsive polymers have been widely used for controlled release of several biomolecules. In general, a single stimulus among various stimuli, for instance, temperature, pH, or light, has been used for these polymers. Although some stimuli are applied together, one cannot control each stimulus independently at a given stimulus-responsive polymer. However, to mimic biological system like cell membrane, multiple on鈥搊ff gates utilizing independent control of dual (or multiple) stimuli shoul...
14 CitationsSource