Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans
Abstract
In response to environmental and dietary cues, the C. elegans orphan nuclear receptor, DAF-12, regulates dauer diapause, reproductive development, fat metabolism, and life span. Despite strong evidence for hormonal control, the identification of the DAF-12 ligand has remained elusive. In this work, we identified two distinct 3-keto-cholestenoic acid metabolites of DAF-9, a cytochrome P450 involved in hormone production, that function as ligands...
Paper Details
Title
Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans
Published Date
Mar 1, 2006
Journal
Volume
124
Issue
6
Pages
1209 - 1223
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History