FOXO-dependent regulation of innate immune homeostasis
Abstract
Most multicellular organisms depend on innate immunity, an ancient host defence mechanism found in both plants and animals, to fight microbial infections. Evolutionarily conserved pathways such as the Toll/Toll-like receptor and immune deficiency and tumour necrosis factor receptor pathways generate antimicrobial peptides as part of the innate immune response. This paper provides evidence that the transcription factor FOXO regulates the...
Paper Details
Title
FOXO-dependent regulation of innate immune homeostasis
Published Date
Jan 21, 2010
Journal
Volume
463
Issue
7279
Pages
369 - 373
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Notes
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