Fitting CRISPR-associated Cas3 into the Helicase Family Tree
Abstract
Helicases utilize NTPs to modulate their binding to nucleic acids and many of these enzymes also unwind DNA or RNA duplexes in an NTP-dependent fashion. These proteins are phylogenetically related but functionally diverse, with essential roles in virtually all aspects of nucleic acid metabolism. A new class of helicases associated with RNA-guided adaptive immune systems in bacteria and archaea has recently been identified. Prokaryotes acquire...
Paper Details
Title
Fitting CRISPR-associated Cas3 into the Helicase Family Tree
Published Date
Feb 1, 2014
Volume
24
Pages
106 - 114
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