Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study

A mycoplasma-encoded purine nucleoside phosphorylase (designated PNP_Hyor) has been cloned and characterized for the first time. Efficient phosphorolysis of natural 6-oxopurine and 6-aminopurine nucleosides was observed, with adenosine the preferred natural substrate (K_m = 61 µM). Several cytostatic purine nucleoside analogs proved to be susceptible to PNP_Hyor-mediated phosphorolysis, and a markedly...