Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
Abstract
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have distinct clinical features but a common pathology--cytoplasmic inclusions rich in transactive response element DNA-binding protein of 43 kDa (TDP43). Rare TDP43 mutations cause ALS or FTD, but abnormal TDP43 levels and localization may cause disease even if TDP43 lacks a mutation. Here we show that individual neurons vary in their ability to clear TDP43 and are...
Paper Details
Title
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
Published Date
Aug 1, 2014
Journal
Volume
10
Issue
8
Pages
677 - 685
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