Cytokine Conditioning Enhances Systemic Delivery and Therapy of an Oncolytic Virus
Abstract
Optimum clinical protocols require systemic delivery of oncolytic viruses in the presence of an intact immune system. We show that preconditioning with immune modulators, or loading virus onto carrier cells ex vivo, enhances virus-mediated antitumor activity. Our early trials of systemic reovirus delivery showed that after infusion reovirus could be recovered from blood cells—but not from plasma—suggesting that rapid association with blood cells...
Paper Details
Title
Cytokine Conditioning Enhances Systemic Delivery and Therapy of an Oncolytic Virus
Published Date
Oct 1, 2014
Journal
Volume
22
Issue
10
Pages
1851 - 1863
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