Hyposmotic challenge modulates function of L-type calcium channel in rat ventricular myocytes through protein kinase C

Published: Oct 18, 2010
Abstract
To study the effects and mechanisms by which hyposmotic challenge modulate function of L-type calcium current (I(Ca,L)) in rat ventricular myocytes.The whole-cell patch-clamp techniques were used to record I(Ca,L) in rat ventricular myocytes.Hyposmotic challenge(∼220 mosmol/L) induced biphasic changes of I(Ca,L), a transient increase followed by a sustained decrease. I(Ca,L) increased by 19.1%±6.1% after short exposure (within 3 min) to...
Paper Details
Title
Hyposmotic challenge modulates function of L-type calcium channel in rat ventricular myocytes through protein kinase C
Published Date
Oct 18, 2010
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