Can we measure serum thyroglobulin

Published on May 1, 2002in Annals of Clinical Biochemistry1.893
· DOI :10.1258/0004563021902125
PM Clark1
Estimated H-index: 1
G Beckett1
Estimated H-index: 1
Measurement of serum thyroglobulin (Tg) by immunoassay is used to monitor the treatment of differentiated thyroid cancer. An understanding of the disease process and the biochemistry of Tg allows the laboratory to determine the characteristics of suitable Tg assays. There are a number of key analytical issues: standardization, long-term assay stability, minimum detection limit, working range and the effect of endogenous Tg antibodies (TgAb). There are signiecant limitations to the methods used to determine TgAb interference. Clinicians should be aware of the limitations of immunoassays for this tumour marker. Ann Clin Biochem 2002; 39: 196-202
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