A gold bullet to treat obesity related metabolic disorders

Objectives: Obesity is associated with chronic low grade inflammation. Adipose resident macrophages (ATMs) in obese individuals are known to produce increased levels of proinflammatory cytokines. We have previously shown that intraperitoneal (IP) injection of 20—30 nm gold nanoparticles (AuNPs) in lean mice can induce significant fat loss along with reduced adiposetissue-derived, tumour necrosis factor (TNF) mRNA expression without a concomitant...