Effects of Ionic Strength and Sugars on the Aggregation Propensity of Monoclonal Antibodies: Influence of Colloidal and Conformational Stabilities

To develop a general strategy for optimizing monoclonal antibody (MAb) formulations. Colloidal stabilities of four representative MAbs solutions were assessed based on the second virial coefficient (B null null null null null null null null null null null null null null null null null null null null null null null null null null 2) at 20°C and 40°C, and net charges at different NaCl concentrations, and/or in the presence of sugars....