Mechanistic Target of Rapamycin Complex 2 Protects the Heart From Ischemic Damage
Abstract
The mechanistic target of rapamycin (mTOR) comprises 2 structurally distinct multiprotein complexes, mTOR complexes 1 and 2 (mTORC1 and mTORC2). Deregulation of mTOR signaling occurs during and contributes to the severity of myocardial damage from ischemic heart disease. However, the relative roles of mTORC1 versus mTORC2 in the pathogenesis of ischemic damage are unknown.Combined pharmacological and molecular approaches were used to alter the...
Paper Details
Title
Mechanistic Target of Rapamycin Complex 2 Protects the Heart From Ischemic Damage
Published Date
Nov 5, 2013
Journal
Volume
128
Issue
19
Pages
2132 - 2144
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