Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain.

Volume: 19, Issue: 10, Pages: 2711 - 2719
Published: May 1, 2004
Abstract
Abnormal phosphorylation of tau is a feature of Alzheimer's disease (AD), which develops prematurely in Down syndrome (DS) patients. Cognitive impairment is also recognized as a clinical characteristic of schizophrenia, which does not appear to be associated with tau-aggregate formation. Several kinases can phosphorylate tau in cell-free assays. Here we show increased activity of mitogen-activated protein kinases (MAPKs) (including ERK1/2, SAPKs...
Paper Details
Title
Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain.
Published Date
May 1, 2004
Volume
19
Issue
10
Pages
2711 - 2719
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.