Failure to deactivate in the prefrontal cortex in schizophrenia: dysfunction of the default mode network?
Abstract
BackgroundFunctional imaging studies using working memory tasks have documented both prefrontal cortex (PFC) hypo- and hyperactivation in schizophrenia. However, these studies have often failed to consider the potential role of task-related deactivation.MethodThirty-two patients with chronic schizophrenia and 32 age- and sex-matched normal controls underwent functional magnetic resonance imaging (fMRI) scanning while performing baseline, 1-back...
Paper Details
Title
Failure to deactivate in the prefrontal cortex in schizophrenia: dysfunction of the default mode network?
Published Date
Aug 1, 2008
Journal
Volume
38
Issue
8
Pages
1185 - 1193
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Notes
History