The effects of aging and neurodegeneration on apoptosis-associated DNA fragmentation and the benefits of nicotinamide

In this work, the tertiary butylhydroperoxide-(t-BuOOH) treated mouse was used as a model to study the oxidative stress that is associated with various neurodegenerative diseases. DNA was found to be an early target oft-BuOOH attack. Necrosis was associated with extensive DNA fragmentation that occurred in almost all regions of the brain within 20 min following intracerebroventricular (icv) injection of 109.7 mg/kgt-BuOOH. Apoptosis was...