Upregulation of presynaptic proteins and protein kinases associated with enhanced glutamate release from axonal terminals (synaptosomes) of the medial prefrontal cortex in rats with neuropathic pain

Summary Neuropathic pain-enhanced glutamate release from the presynaptic terminals of the medial prefrontal cortex is associated with upregulation of synaptic proteins and the ERK1/2- and CaMKII-synapsin I signaling pathway. Although nerve injury-induced long-term postsynaptic changes have been investigated, less is known regarding the molecular mechanisms within presynaptic axonal terminals. We investigated the molecular changes in presynaptic...