Modeling of latent structure of indomethacin solid dispersion tablet using Bayesian networks

When designing pharmaceutical products, the relationships between causal factors and pharmaceutical responses are intricate. A Bayesian network (BN) was used to clarify the latent structure underlying the causal factors and pharmaceutical responses of a tablet containing solid dispersion (SD) of indomethacin (IMC).IMC, a poorly water-soluble drug, was tested with polyvinylpyrrolidone as the carrier polymer. Tablets containing a SD or a physical...