Function and information content of DNA methylation
Abstract
Cytosine methylation is a DNA modification generally associated with transcriptional silencing. Factors that regulate methylation have been linked to human disease, yet how they contribute to malignances remains largely unknown. Genomic maps of DNA methylation have revealed unexpected dynamics at gene regulatory regions, including active demethylation by TET proteins at binding sites for transcription factors. These observations indicate that...
Paper Details
Title
Function and information content of DNA methylation
Published Date
Jan 14, 2015
Journal
Volume
517
Issue
7534
Pages
321 - 326
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