Original paper
Aerobically Derived Lactate Stimulates Revascularization and Tissue Repair via Redox Mechanisms
Abstract
Hypoxia serves as a physiologic cue to drive an angiogenic response via HIF-dependent mechanisms. Interestingly, minor elevation of lactate levels in the tissue produces the same effect under aerobic conditions. Aerobic glycolysis contributes to lactate accumulation in the presence of oxygen, especially under inflammatory conditions. We previously postulated that aerobic lactate accumulation, already known to stimulate collagen deposition, will...
Paper Details
Title
Aerobically Derived Lactate Stimulates Revascularization and Tissue Repair via Redox Mechanisms
Published Date
Aug 1, 2007
Volume
9
Issue
8
Pages
1115 - 1124
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Notes
History