Antagonism of corticotropin-releasing factor receptors in the locus coeruleus attenuates shock-induced freezing in rats
Abstract
Intracerebroventricularly administered alpha-helical CRF9-41, a corticotropin-releasing factor (CRF) receptor antagonist, is known to reduce a variety of stress-induced behavioral responses. This study examined in rats whether antagonism of CRF receptors in the region of locus coeruleus (LC) plays a role in reducing freezing induced by electric foot shock. Freezing is a well-characterized defensive response to stress and has been demonstrated to...
Paper Details
Title
Antagonism of corticotropin-releasing factor receptors in the locus coeruleus attenuates shock-induced freezing in rats
Published Date
Aug 1, 1992
Journal
Volume
587
Issue
2
Pages
263 - 268
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