Association of Insulin-Like Growth Factor-I with Body Composition, Weight History, and Past Health Behaviors in the Very Old: The Framingham Heart Study

OBJECTIVES: We examined correlates of insulin-like growth factor-I (IGF-I), an indicator of growth hormone levels, to identify factors associated with higher levels of IGF-I in old age. DESIGN: Nested study of cross-sectional correlates and early-life predictors of IGF-I level. SETTING: A longitudinal cohort study, the Framingham Heart Study. PARTICIPANTS: A total of 790 men and women (mean age 78.5, range 72–94), who had weight, waist and hip...