Porous silicon in drug delivery devices and materials

Published on Aug 17, 2008in Advanced Drug Delivery Reviews15.519
· DOI :10.1016/j.addr.2008.03.017
Emily J. Anglin7
Estimated H-index: 7
(UCSD: University of California, San Diego),
Lingyun Cheng31
Estimated H-index: 31
(UCSD: University of California, San Diego)
+ 1 AuthorsMichael J. Sailor73
Estimated H-index: 73
(UCSD: University of California, San Diego)
Porous Si exhibits a number of properties that make it an attractive material for controlled drug delivery applications: The electrochemical synthesis allows construction of tailored pore sizes and volumes that are controllable from the scale of microns to nanometers; a number of convenient chemistries exist for the modification of porous Si surfaces that can be used to control the amount, identity, and in vivo release rate of drug payloads and the resorption rate of the porous host matrix; the material can be used as a template for organic and biopolymers, to prepare composites with a designed nanostructure; and finally, the optical properties of photonic structures prepared from this material provide a self-reporting feature that can be monitored in vivo. This paper reviews the preparation, chemistry, and properties of electrochemically prepared porous Si or SiO2 hosts relevant to drug delivery applications.
  • References (191)
  • Citations (572)
📖 Papers frequently viewed together
456 Citations
1,071 Citations
1,925 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Jarno Salonen (UTU: University of Turku)H-Index: 51
#2Ann Marie Kaukonen (UH: University of Helsinki)H-Index: 18
Last. Vesa-Pekka Lehto (UTU: University of Turku)H-Index: 35
view all 4 authors...
During the last few years, a number of interesting drug delivery applications of mesoporous materials have been demonstrated. Mesoporous silicon has many important properties advantageous to drug delivery applications. The small size of the pores confines the space of a drug and engages the effects of surface interactions of the drug molecules and the pore wall. The size of the pores and the surface chemistry of the pore walls may be easily changed and controlled. Depending on the size and the s...
339 CitationsSource
#1Jason Dorvee (UCSD: University of California, San Diego)H-Index: 3
#2Michael J. Sailor (UCSD: University of California, San Diego)H-Index: 73
Last. Gordon M. Miskelly (University of Auckland)H-Index: 24
view all 3 authors...
Digital microfluidics involves the manipulation of molecules and materials in discrete packages. This paper reviews our work using amphiphilic magnetic microparticles constructed from porous silicon. An individual porous particle can be used to carry a nanomole or smaller quantities of a reagent, and assemblies of the particles can encapsulate and transport microliter droplets of liquid containing inorganic, organic, or biological molecules. The tracking and identification of each particle can b...
36 CitationsSource
#1Kristopher A. Kilian (UIUC: University of Illinois at Urbana–Champaign)H-Index: 28
#2Till Böcking (USYD: University of Sydney)H-Index: 30
Last. J. Justin Gooding (USYD: University of Sydney)H-Index: 63
view all 5 authors...
The organic derivatization of silicon-based nanoporous photonic crystals is presented as a method to immobilize peptides for the detection of protease enzymes in solution. A narrow-line-width rugate filter, a one-dimensional photonic crystal, is fabricated that exhibits a high-reflectivity optical resonance that is sensitive to small changes in the refractive index at the pore walls. To immobilize peptide in the pore of the photonic crystal, the hydrogen-terminated silicon surface was first modi...
85 CitationsSource
#1Tarja Limnell (UH: University of Helsinki)H-Index: 5
#2Joakim Riikonen (UTU: University of Turku)H-Index: 19
Last. V.-P. Lehto (UTU: University of Turku)H-Index: 15
view all 7 authors...
Six different types of mesoporous silicon microparticles were prepared to evaluate the effect of surface treatment and pore sizes on their properties as drug carriers. The studied porous silicon particles were as-anodized, thermally carbonized (TCPSi) and thermally oxidized (TOPSi) in addition to three novel ones: annealed TCPSi, annealed TOPSi and thermally hydrocarbonized porous silicon (THCPSi). Drug dissolution at pH 5.5 and physical and chemical stabilities after 3 months of storage were us...
77 CitationsSource
#1Brian G. Trewyn (Iowa State University)H-Index: 33
#2Supratim Giri (Iowa State University)H-Index: 14
Last. Victor S.-Y. Lin (Iowa State University)H-Index: 44
view all 4 authors...
Recent advancements in controlling the surface properties and particle morphology of the structurally defined mesoporous silica materials with high surface area (>700 m2 g−1) and pore volume (>1 cm3 g−1) have significantly enhanced their biocompatibility. Various methods have been developed for the functionalization of both the internal pore and exterior particle surfaces of these silicates with a tunable pore diameter ranging from 2 to 30 nm and a narrow pore size distribution. Herein, we revie...
177 CitationsSource
#1Kristopher A. Kilian (UNSW: University of New South Wales)H-Index: 28
#2Till Böcking (UNSW: University of New South Wales)H-Index: 30
Last. J. Justin Gooding (UNSW: University of New South Wales)H-Index: 63
view all 5 authors...
Porous silicon has shown potential for various applications in biology and medicine, which require that the material (1) remain stable for the length of the intended application and (2) resist non-specific adsorption of proteins. Here we explore the efficacy of short oligo(ethylene glycol) moieties incorporated into organic layers via two separate strategies in achieving these aims. In the first strategy the porous silicon structure was modified in a single step via hydrosilylation of α-oligo(et...
56 CitationsSource
#1Chongmu Lee (IIT: Inha University)H-Index: 34
#2Hojin Kim (IIT: Inha University)H-Index: 1
Last. Wan In Lee (IIT: Inha University)H-Index: 30
view all 4 authors...
Photodynamic therapy (PDT) is a very useful approach for cancer treatment, but it has a few short-term and long-term side effects arising from reactive oxygen species (ROS) generation. Recently a new photodynamic therapy (PDT) based not on the ROS generation capability of photosensitizers but on the heat generation capability of carbon nanotubes (CNT) combined with a near-infrared (NIR) light irradiation technique has received significant attention. Our experimental results show that PSi can als...
30 CitationsSource
#1Ann Marie Kaukonen (UH: University of Helsinki)H-Index: 18
#2Leena Laitinen (UH: University of Helsinki)H-Index: 13
Last. Vesa-Pekka Lehto (UTU: University of Turku)H-Index: 35
view all 8 authors...
The combined release and permeation behavior of furosemide loaded into thermally carbonized mesoporous silicon (TCPSi) microparticles was studied in order to evaluate the potential of TCPSi-loading to improve permeation of furosemide, a BCS class IV compound. Permeation was studied across Caco-2 monolayers at pH 5.5, 6.8 and 7.4 from drug solutions and TCPSi particles. TCPSi-loaded furosemide (39% w/w) exhibited improved dissolution from the microparticles with greatly diminished pH dependence. ...
71 CitationsSource
Very high surface area silicon powders can be realized by high energy milling or electrochemical etching techniques. Such nanoscale silicon structures, whilst biodegradable in the human gastrointestinal tract, are shown to be remarkably stable in most foodstuffs and beverages. The potential for using silicon to improve the shelf life and bioavailability of specific nutrients in functional foods is highlighted. Published drug delivery data implies that the nanoentrapment of hydrophobic nutrients ...
79 CitationsSource
#1Ester Segal (UCSD: University of California, San Diego)H-Index: 24
#2Loren A. Perelman (UCSD: University of California, San Diego)H-Index: 6
Last. Michael J. Sailor (UCSD: University of California, San Diego)H-Index: 73
view all 7 authors...
A thermoresponsive hydrogel, poly(N-isopropylacrylamide) (poly(NIPAM)), is synthesized in situ within an oxidized porous Si template, and the nanocomposite material is characterized. Infiltration of the hydrogel into the interconnecting nanoscale pores of the porous SiO 2 host is confirmed by scanning electron microscopy. The optical reflectivity spectrum of the nanocomposite hybrid displays Fabry-Perot fringes characteristic of thin film interference, enabling direct, real-time observation of t...
80 CitationsSource
Cited By572
#1Panoraia I. Siafaka (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 12
#2Neslihan Üstündağ Okur (UHSA: University of Health Sciences Antigua)H-Index: 3
Last. Evren Gundogdu (Ege University)H-Index: 7
view all 5 authors...
Abstract In the last decade, the use of nanotheranostics as emerging diagnostic and therapeutic tools for various diseases, especially cancer, is held of great attention. Up to date, several approaches have been employed in order to develop smart nanotheranostics, which combine bioactive targeting on specific tissues as well as diagnostic properties. The nanotheranostics can deliver therapeutic agents by concomitantly monitor the therapy response in real-time. Consequently, the possibility of ov...
#1Yaoyao Sun (UCSD: University of California, San Diego)H-Index: 1
#2Kristyn Huffman (UCSD: University of California, San Diego)H-Index: 2
Last. Lingyun Cheng (UCSD: University of California, San Diego)H-Index: 31
view all 5 authors...
Mesoporous silica has attracted significant attention in the drug delivery area; however, impurities can be a source of toxicity. The current study used commercial microparticles produced at large ...
#1Xiaoyue Gong (François Rabelais University)
#2Julien Bustillo (François Rabelais University)H-Index: 4
Last. Gaël Gautier (François Rabelais University)H-Index: 14
view all 4 authors...
Abstract Porous silicon (PSi) seems to be a promising material for acoustic transducers due to its manufacturing ease and high abilities. Yet, the investigation on wave propagation in this porous material is required to enhance the sensitivity. According to Biot’s theory, wave propagation is governed by the porous matrix moduli (i.e. Young’s modulus, bulk modulus, and shear modulus). These parameters as well as Poisson ratios are difficult to measure and are often estimated using ultrasonic meas...
1 CitationsSource
#1Chetan SharmaH-Index: 2
#2Nalin H. ManiyaH-Index: 5
Last. Sanjaykumar R. PatelH-Index: 8
view all 4 authors...
#1M. B. Gongalsky (MSU: Moscow State University)H-Index: 12
#2A. P. Sviridov (MSU: Moscow State University)H-Index: 6
Last. Liubov A. Osminkina (MSU: Moscow State University)H-Index: 16
view all 4 authors...
Abstract Development of porous silicon-based drug delivery systems for theranostics requires a precise control of their biodegradation. Thus, we propose a model for the biodegradation of porous silicon nanoparticles (PSi NPs) based on a diffusion equation combined with Nernst-Brunner mass transfer equation describing the dissolution of silicon and formation of silicic acid (SA). The spatiotemporal distributions of PSi NP porosity and SA concentration were calculated. The model was successfully a...
Abstract The natural biodegradabilty of porous silicon (pSi) in physiological media limits its wider usage for implantable systems. We report the stabilization of porous silicon (pSi) membranes by chemical surface oxidation using RCA1 and RCA2 protocols, which was followed by a PEGylation process using a silane-PEG. These surface modifications stabilized the pSi to allow a long period of immersion in PBS, while leaving the pSi surface sufficiently hydrophilic for good filtration and diffusion of...
1 CitationsSource
#1Safoura Rezaei (TMU: Tarbiat Modares University)
#2Bahareh Dabirmanesh (TMU: Tarbiat Modares University)H-Index: 10
Last. Khosro Khajeh (TMU: Tarbiat Modares University)H-Index: 26
view all 6 authors...
Abstract Removal of chondroitin sulfate proteoglycans (CSPGs) with chondroitinase ABC I (ChABC) facilitates axonal plasticity, axonal regeneration and remyelination, following injury to the central nervous system (CNS). However, the ChABC rapidly undergoes thermal inactivity and needs to be injected repeatedly. Here this limitation was overcame by immobilizing the ChABC on porous silicon (PSi) nanoparticles (ChABC@PSi). The efficacy of immobilized ChABC on CSPGs level and the demyelination insul...
#1G.L. Sharipov (RAS: Russian Academy of Sciences)H-Index: 5
#2A. M. Abdrakhmanov (RAS: Russian Academy of Sciences)H-Index: 7
Last. A.A. Tukhbatullin (RAS: Russian Academy of Sciences)H-Index: 5
view all 4 authors...
Abstract Aqueous suspensions of silicon dioxide porous nanoparticles (average size 10-30 nm, average pore size 5.8 nm) were obtained via ultrasonic dispersing. As was shown through recording SiO molecular lines in a moving single-bubble sonoluminescence spectrum, these nanoparticles penetrate into the bubble and then undergo decay. Similarly, suspensions of SiO2 nanoparticles, the pores of which were saturated with ruthenium dodecacarbonyl or elemental sulfur, were obtained by impregnation of th...