Notch3 Functions as a Tumor Suppressor by Controlling Cellular Senescence
Abstract
Notch signaling regulates a broad spectrum of cell fate decisions and differentiation. Both oncogenic and tumor suppressor functions have been shown for Notch signaling. However, little is known about the underlying mechanisms of its tumor suppressor function. Here, we report that expression of Notch3, a member of Notch family transmembrane receptors, was elevated in human cells during senescence activated by various senescence-inducing stimuli....
Paper Details
Title
Notch3 Functions as a Tumor Suppressor by Controlling Cellular Senescence
Published Date
May 30, 2013
Journal
Volume
73
Issue
11
Pages
3451 - 3459
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