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News Feature: Asia's big problem
Published on Apr 1, 2004in Nature Medicine 32.62
· DOI :10.1038/nm0404-325
Apoorva Mandavilli7
Estimated H-index: 7
,
David Cyranoski10
Estimated H-index: 10
Abstract
All the world loves to mock obese Americans, but weightier issues lurk in Asia, where diabetes and heart disease run rampant. The first hurdle may be a Western measure that is blind to the expanding fat in Asians' deceptively thin bodies.
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Published on Jan 1, 2006in Contributions To Nephrology 0.93
Kunitoshi Iseki58
Estimated H-index: 58
Background: There is a worldwide obesity epidemic, and the number of patients requiring dialysis because of obesity-related renal disease such as diabetes mellitus and hypertension is increasing. Ob
27 Citations Source Cite
Published on Jun 1, 2012in Journal of Diabetes Investigation 3.15
Hiromi Iwahashi27
Estimated H-index: 27
,
Yukiyoshi Okauchi13
Estimated H-index: 13
+ 9 AuthorsTadashi Nakamura52
Estimated H-index: 52
Aims/Introduction: Pronounced reduction of insulin secretion in response to a rise in glucose level has been reported in Japanese patients compared with Caucasian patients, but the mean body mass index (BMI) is also lower in Japanese patients. As BMI is a determinant of insulin secretion, we examined insulin-secretion capacity in obese and non-obese Japanese patients. Materials and Methods: Using the oral glucose tolerance test (OGTT), we estimated the insulin-secreting capacity in obese (BMI ≥ ...
16 Citations Source Cite
Published on Jun 1, 2011in Journal of Diabetes Investigation 3.15
Norio Harada16
Estimated H-index: 16
(Kyoto University),
Akihiro Hamasaki17
Estimated H-index: 17
(Kyoto University)
+ 4 AuthorsNobuya Inagaki46
Estimated H-index: 46
(Kyoto University)
Aims/Introduction: Gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are major incretins that potentiate insulin secretion from pancreatic β-cells. The factors responsible for incretin secretion have been reported in Caucasian subjects, but have not been thoroughly evaluated in Japanese subjects. We evaluated the factors associated with incretin secretion during oral glucose tolerance test (OGTT) in Japanese subjects with normal glucose tolerance (NGT). Materials and Metho...
18 Citations Source Cite
Published on Feb 1, 2012in Journal of Diabetes Investigation 3.15
Shunsuke Yamane13
Estimated H-index: 13
(Kyoto University),
Norio Harada16
Estimated H-index: 16
(Kyoto University)
+ 8 AuthorsShin-ichi Harashima10
Estimated H-index: 10
(Kyoto University)
Aims/Introduction: Gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are the major incretins; their secretion after various nutrient loads are well-evaluated in Caucasians. However, little is known of the relationship between incretin secretion and differing nutritional loading in Japanese subjects. In the present study, we evaluated GIP and GLP-1 secretion in Japanese subjects with normal glucose tolerance (NGT) after glucose loading (75 g glucose and 17 g glucose) and me...
21 Citations Source Cite
Published on Jan 1, 2006in Nature Medicine 32.62
Yoshio Yazaki96
Estimated H-index: 96
,
Takashi Kadowaki119
Estimated H-index: 119
(University of Tokyo)
Medical services in Japan are public. This health system ensures free access to medical facilities for all Japanese citizens under universal insurance coverage and, as a result, the life expectancy of the Japanese population has become the world's longest (mean, 81.8 years). The cost of medical services now accounts for 7.7% of the gross domestic product of Japan, and is the second lowest in the developed world, after the UK. In 2000, the World Health Organization ranked Japan's medical services...
39 Citations Source Cite
Published on Dec 1, 2004in Clinical and Experimental Nephrology 2.02
Richard J. Glassock1
Estimated H-index: 1
The prevalence of end-stage renal disease (ESRD) is rising throughout the developed and developing world, although the rate of increase may be attenuating in some regions. Type 2 diabetes mellitus, often a consequence of obesity and accompanied by the metabolic syndrome, is a major cause of progressive renal disease and the increasing global burden of ESRD. Strategies that are cost-effective and applicable at the community level are urgently needed to stem the tide of both type 2 diabetes and th...
16 Citations Source Cite
Published on Jan 1, 2008in Kidney & Blood Pressure Research 3.00
Ji-Won Lee16
Estimated H-index: 16
,
Urhee Bae2
Estimated H-index: 2
(Yonsei University)
+ 3 AuthorsJohn A. Linton15
Estimated H-index: 15
Aims: It was the aim of this study to investigate the relationship between normal renal function – estimated glomerular filtration rate (GFR) – and visceral adiposity measured by CT
3 Citations Source Cite
Published on Jan 1, 2006in Kidney International 8.43
H. Tanaka1
Estimated H-index: 1
,
Yoshiki Shiohira7
Estimated H-index: 7
+ 2 AuthorsKunitoshi Iseki58
Estimated H-index: 58
We assessed the prevalence of chronic kidney disease (CKD) in a hospital-based screening program in Okinawa, Japan. The significance of metabolic syndrome as a determinant of CKD was examined using multivariate logistic regression analysis. A total of 6980 participants, aged 30–79 years, participated in a screening program in Tomishiro Chuo Hospital. Metabolic syndrome was defined according to the criteria of the Adult Treatment Panel III (ATP III). Data were also analyzed according to the modif...
179 Citations Source Cite
Published on Apr 1, 2011in Metabolism-clinical and Experimental 5.96
Lulu Chen16
Estimated H-index: 16
(Huazhong University of Science and Technology),
Xiang Hu8
Estimated H-index: 8
(Huazhong University of Science and Technology)
+ 8 AuthorsXiu-ling Deng2
Estimated H-index: 2
(Huazhong University of Science and Technology)
Abstract This study was designed to explore the metabolic changes resulting from catch-up growth in adult (CUGA) induced by varying degrees of nutrition promotion after undernutrition and to confirm whether these changes are transient or not. The CUGA models were developed on rats refed on intakes of normal chow or high-fat diet after a period of caloric restriction. The growth of the rats measured by body weight and length stagnated during caloric restriction and then rapidly accelerated follow...
15 Citations Source Cite
Published on Oct 1, 2005in Diabetes Research and Clinical Practice 2.55
Yuichi Nishi18
Estimated H-index: 18
(Kyoto University),
Mitsuo Fukushima34
Estimated H-index: 34
(Kyoto University)
+ 8 AuthorsYutaka Seino56
Estimated H-index: 56
(Kyoto University)
Abstract Impaired fasting glucose (IFG) is a subgroup of impaired glucose regulation exhibiting an elevated fasting glucose levels without elevated 2-h glucose levels on oral glucose tolerance test (OGTT). Diabetes mellitus with isolated fasting hyperglycemia (DM/IFH) is a similar subgroup of diabetes having higher fasting glucose levels with 2-h glucose levels within the non-diabetic range. The aim of this study is to profile the characteristics of these subgroups to estimate the factors involv...
22 Citations Source Cite
View next paperBody mass index and the risk of development of end-stage renal disease in a screened cohort