[+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats.

Volume: 175, Issue: 1, Pages: 387 - 395
Published: Sep 25, 2008
Abstract
null null The toxicity of organophosphorous (OP) nerve agents is attributed to their irreversible inhibition of acetylcholinesterase (AChE), which leads to excessive accumulation of acetylcholine (ACh) and is followed by the release of excitatory amino acids (EAA). EAAs sustain seizure activity and induce neuropathology due to over-stimulation of null N -methyl- d -aspartate (NMDA) receptors. Huperzine A (Hup A), a blood–brain barrier permeable...
Paper Details
Title
[+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats.
Published Date
Sep 25, 2008
Volume
175
Issue
1
Pages
387 - 395
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