Original paper
Efficient synthesis of mibefradil analogues: an insight into in vitro stability
Volume: 12, Issue: 30, Pages: 5669 - 5669
Published: Jun 25, 2014
Abstract
This article describes the synthesis and biological evaluation of a chemical library of mibefradil analogues to investigate the effect of structural modification on in vitro stability. The construction of the dihydrobenzopyran structure in mibefradil derivatives 2 was achieved through two efficient approaches based on a diastereoselective intermolecular Reformatsky reaction and an intramolecular carbonyl–ene cyclization. In particular, the...
Paper Details
Title
Efficient synthesis of mibefradil analogues: an insight into in vitro stability
Published Date
Jun 25, 2014
Volume
12
Issue
30
Pages
5669 - 5669
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Notes
History