Pax5 inducesV-to-DJrearrangements and locus contraction of theimmunoglobulin heavy-chaingene
Abstract
The subnuclear location and chromatin state of the immunoglobulin heavy-chain (IgH) locus have been implicated in the control of VDJ recombination. VH-to-DJH rearrangement of distal, but not proximal V(H) genes, furthermore, depends on the B-lineage commitment factor Pax5 (BSAP). He e we demonstrate that ectopic Pax5 expression from the Ikaros promote induces proximal rather than distal VH-DJH rearrangements in Ik(Pax5/+) thymocytes, thus...
Paper Details
Title
Pax5 inducesV-to-DJrearrangements and locus contraction of theimmunoglobulin heavy-chaingene
Published Date
Feb 15, 2004
Journal
Volume
18
Issue
4
Pages
411 - 422
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