Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

The role of type I interferon in bacterial infection is poorly understood. Sad and colleagues demonstrate that Salmonella-triggered production of type I interferon induces macrophage necroptosis, evasion of the immune response and dissemination of bacteria. Salmonella enterica serovar Typhimurium (S. Typhimurium) is a virulent pathogen that induces rapid host death. Here we observed that host survival after infection with S. Typhimurium was...